RMS Titanic sets sail from Southampton, England on her maiden and only voyage.

RMS Titanic was a British ocean liner that sank in the early hours of 15 April 1912 as a result of striking an iceberg on her maiden voyage from Southampton, England, to New York City, United States. Of the estimated 2,224 passengers and crew aboard, approximately 1,500 died, making the incident one of the deadliest peacetime sinkings of a single ship. Titanic, operated by White Star Line, carried some of the wealthiest people in the world, as well as hundreds of emigrants from the British Isles, Scandinavia, and elsewhere in Europe who were seeking a new life in the United States and Canada. The disaster drew public attention, spurred major changes in maritime safety regulations, and inspired a lasting legacy in popular culture. It was the second time White Star Line had lost a ship on her maiden voyage, the first being RMS Tayleur in 1854.

Southampton is a port city and unitary authority in Hampshire, England. It is located approximately 80 miles (130 km) southwest of London, 20 miles (32 km) west of Portsmouth, and 20 miles (32 km) southeast of Salisbury. Southampton had a population of 253,651 at the 2011 census, making it one of the most populous cities in southern England.