Four hundred fifty prisoners rioted at the Southern Ohio Correctional Facility in Lucasville, Ohio, and continued to do so for ten days, citing grievances related to prison conditions, as well as the forced vaccination of Nation of Islam prisoners (for tuberculosis) against their religious beliefs.

A prison riot is an act of concerted defiance or disorder by a group of prisoners against the prison administrators, prison officers, or other groups of prisoners.

The Southern Ohio Correctional Facility is a maximum security prison located just outside Lucasville in Scioto County, Ohio. The prison was constructed in 1972. As of 2023, the warden is Cindy Davis.

Lucasville is a census-designated place (CDP) in Scioto County, Ohio, United States. The population was 1,655 at the 2020 census. It is part of the Portsmouth micropolitan area.

Incarceration in the United States is one of the primary means of punishment for crime in the United States. In 2021, over five million people were under supervision by the criminal justice system, with nearly two million people incarcerated in state or federal prisons and local jails. The United States has the largest known prison population in the world. It has 5% of the world’s population while having 20% of the world’s incarcerated persons. China, with more than four times more inhabitants, has fewer persons in prison. Prison populations grew dramatically beginning in the 1970s, but began a decline around 2009, dropping 25% by year-end 2021.

Vaccination is the administration of a vaccine to help the immune system develop immunity from a disease. Vaccines contain a microorganism or virus in a weakened, live or killed state, or proteins or toxins from the organism. In stimulating the body's adaptive immunity, they help prevent sickness from an infectious disease. When a sufficiently large percentage of a population has been vaccinated, herd immunity results. Herd immunity protects those who may be immunocompromised and cannot get a vaccine because even a weakened version would harm them. The effectiveness of vaccination has been widely studied and verified. Vaccination is the most effective method of preventing infectious diseases; widespread immunity due to vaccination is largely responsible for the worldwide eradication of smallpox and the elimination of diseases such as polio and tetanus from much of the world. According to the World Health Organization (WHO), vaccination prevents 3.5–5 million deaths per year. A WHO-funded study by The Lancet estimates that, during the 50-year period starting in 1974, vaccination prevented 154 million deaths, including 146 million among children under age 5. However, some diseases have seen rising cases due to relatively low vaccination rates attributable partly to vaccine hesitancy.