The first launch of a Space Shuttle (Columbia) takes place: The STS-1 mission.

The Space Shuttle is a retired, partially reusable low Earth orbital spacecraft system operated from 1981 to 2011 by the U.S. National Aeronautics and Space Administration (NASA) as part of the Space Shuttle program. Its official program name was the Space Transportation System (STS), taken from the 1969 plan led by U.S. vice president Spiro Agnew for a system of reusable spacecraft where it was the only item funded for development.

Space Shuttle Columbia (OV-102) was a Space Shuttle orbiter manufactured by Rockwell International and operated by NASA. Named after the first American ship to circumnavigate the globe, and the female personification of the United States, Columbia was the first of five Space Shuttle orbiters to fly in space, debuting the Space Shuttle launch vehicle on its maiden flight on April 12, 1981 and becoming the first spacecraft to be re-used after its first flight when it launched on STS-2 on November 12, 1981. As only the second full-scale orbiter to be manufactured after the Approach and Landing Test vehicle Enterprise, Columbia retained unique external and internal features compared to later orbiters, such as test instrumentation and distinctive black chines. In addition to a heavier aft fuselage and the retention of an internal airlock throughout its lifetime, these made Columbia the heaviest of the five spacefaring orbiters: around 1,000 kilograms heavier than Challenger and 3,600 kilograms heavier than Endeavour when originally constructed. Columbia also carried ejection seats based on those from the SR-71 during its first six flights until 1983, and from 1986 onwards carried an imaging pod on its vertical stabilizer.

STS-1 was the first orbital spaceflight of NASA's Space Shuttle program. The first orbiter, Columbia, launched on April 12, 1981, and returned on April 14, 1981, 54.5 hours later, having orbited the Earth 37 times. Columbia carried a crew of two—commander John W. Young and pilot Robert L. Crippen. It was the first American crewed space flight since the Apollo–Soyuz Test Project (ASTP) in 1975. STS-1 was also the maiden test flight of a new American spacecraft to carry a crew, though it was preceded by atmospheric testing (ALT) of the orbiter and ground testing of the Space Shuttle system.