Serse, an opera by Baroque composer George Frideric Handel loosely based on Xerxes I of Persia, premiered in London.

Serse is an opera seria in three acts by George Frideric Handel. It was first performed in London on 15 April 1738. The Italian libretto was adapted by an unknown hand from that by Silvio Stampiglia (1664–1725) for an earlier opera of the same name by Giovanni Bononcini in 1694. Stampiglia's libretto was itself based on one by Nicolò Minato (ca.1627–1698) that was set by Francesco Cavalli in 1654. The opera is set in Persia about 470 BC and is very loosely based upon Xerxes I of Persia. Serse, originally sung by a mezzo-soprano castrato, is now usually performed by a female mezzo-soprano or countertenor.

Baroque music refers to the period or dominant style of Western classical music composed from about 1600 to 1750. The Baroque style followed the Renaissance period, and was followed in turn by the Classical period after a short transition. The Baroque period is divided into three major phases: early, middle, and late. Overlapping in time, they are conventionally dated from 1580 to 1650, from 1630 to 1700, and from 1680 to 1750. Baroque music forms a major portion of the "classical music" canon, and continues to be widely studied, performed, and listened to. The term "baroque" comes from the Portuguese word barroco, meaning "misshapen pearl". Key composers of the Baroque era include Johann Sebastian Bach, Antonio Vivaldi, George Frideric Handel, Georg Philipp Telemann, Domenico Scarlatti, Claudio Monteverdi, Alessandro Stradella, Jean-Baptiste Lully, Jean-Philippe Rameau, Arcangelo Corelli, François Couperin, Heinrich Schütz, Dieterich Buxtehude, and Heinrich Ignaz Franz Biber.

George Frideric Handel was a German-British Baroque composer well-known for his operas, oratorios, anthems, concerti grossi, and organ concerti.

Xerxes I, commonly known as Xerxes the Great, was a Persian ruler who served as the fourth King of Kings of the Achaemenid Empire, reigning from 486 BC until his assassination in 465 BC. He was the son of Darius the Great and Atossa, a daughter of Cyrus the Great.