Caleb Blood Smith, American journalist, lawyer, and politician, sixth United States Secretary of the Interior (died 1864)

Caleb Blood Smith was a United States Representative from Indiana, the 6th United States Secretary of the Interior and a United States district judge of the United States District Court for the District of Indiana.

The United States secretary of the interior is the head of the United States Department of the Interior. The secretary and the Department of the Interior are responsible for the management and conservation of most federal land along with natural resources, leading such agencies as the Bureau of Land Management, the United States Geological Survey, the Bureau of Indian Affairs and the National Park Service. The secretary also serves on and appoints the private citizens on the National Park Foundation Board. The secretary is a member of the United States Cabinet and reports to the president of the United States. The function of the U.S. Department of the Interior is different from that of the interior minister designated in many other countries.