A series of gas explosions rip through the streets in Guadalajara, Mexico, killing 206.

A gas explosion is the ignition of a mixture of air and flammable gas, typically from a gas leak. In household accidents, the principal explosive gases are those used for heating or cooking purposes such as methane, propane, or butane. In industrial explosions, many other gases, like hydrogen, as well as evaporated (gaseous) gasoline or ethanol play an important role. Industrial gas explosions can be prevented with the use of intrinsic safety barriers to prevent ignition, or use of alternative energy.

A series of ten explosions took place on April 22, 1992, in the downtown district of Analco Colonia Atlas in Guadalajara city, Jalisco state, Mexico. Numerous gasoline explosions in the sewer system and fires over four hours destroyed 8 kilometres (5.0 mi) of streets. Gante Street was the most damaged.

Guadalajara is the capital and the most populous city in the western Mexican state of Jalisco, as well as the most densely populated municipality in Jalisco. According to the 2020 census, the city has a population of 1,385,629 people, making it the 8th most populous city in Mexico, while the Guadalajara metropolitan area has a population of 5,268,642, making it the third-largest metropolitan area in the country and the twenty-second largest metropolitan area in the Americas. Guadalajara has the second-highest population density in Mexico with over 10,361 people per km², surpassed only by Mexico City. Within Mexico, Guadalajara is a center of business, arts and culture, technology and tourism; as well as the economic center of the Bajío region. It usually ranks among the 100 most productive and globally competitive cities in the world. It is home to numerous landmarks, including the Guadalajara Cathedral, Degollado Theatre, the Templo Expiatorio, the UNESCO World Heritage site Hospicio Cabañas, and the San Juan de Dios Market—the largest indoor market in Latin America.