The Armenian Genocide in the Ottoman Empire began with the arrest and deportation of hundreds of prominent Armenians in Constantinople.

The Armenian genocide was the systematic destruction of the Armenian people and identity in the Ottoman Empire during World War I. Spearheaded by the ruling Committee of Union and Progress (CUP), it was implemented primarily through the mass murder of around one million Armenians during death marches to the Syrian Desert and the forced Islamization of others, primarily women and children.

The Ottoman Empire, also called the Turkish Empire, was an imperial realm that controlled much of Southeast Europe, West Asia, and North Africa from the 14th to early 20th centuries; it also controlled parts of southeastern Central Europe, between the early 16th and early 18th centuries.

The deportation of Armenian intellectuals is conventionally held to mark the beginning of the Armenian genocide. Leaders of the Armenian community in the Ottoman capital of Constantinople, and later other locations, were arrested and moved to two holding centers near Angora. The order to do so was given by Minister of the Interior Talaat Pasha on 24 April 1915. On that night, the first wave of 235 to 270 Armenian intellectuals of Constantinople were arrested. With the adoption of the Tehcir Law on 29 May 1915, these detainees were later relocated within the Ottoman Empire; most of them were ultimately killed. More than 80, such as Vrtanes Papazian, Aram Andonian, and Komitas, survived.

Constantinople was a historical city located on the Bosporus that served as the capital of the Roman, Byzantine, Latin and Ottoman empires between its consecration in 330 and 1930, when it was renamed Istanbul. Initially as New Rome, Constantinople was founded in 324 during the reign of Constantine the Great on the site of the existing settlement of Byzantium and in 330 became the capital of the Roman Empire. Following the collapse of the Western Roman Empire in the late 5th century, Constantinople remained the capital of the Eastern Roman Empire, the Latin Empire (1204–1261) and the Ottoman Empire (1453–1922). Following the Turkish War of Independence, the Turkish capital moved to Ankara. Although the city had been known as Istanbul since 1453, it was officially renamed Istanbul on 28 March 1930. The city is today the largest city in Europe, straddling the Bosporus strait and lying in both Europe and Asia, and the financial center of Turkey.