Fifty-five tornadoes break out in the central United States. Before the outbreak's end, Andover, Kansas, would record the year's only F5 tornado.

From April 26 to 27, 1991, multiple supercells across Oklahoma and Kansas led to a regional tornado outbreak. Forced by a potent trough and focused along a dryline, these distinct thunderstorms moved northeast through a moist and highly unstable environment. A total of 55 tornadoes were confirmed, many of which were strong, F2 or greater on the Fujita scale. A widely documented F5 tornado tore through Andover, Kansas, killing 17 people. Additional fatalities occurred from significant tornadoes in other portions of Kansas and Oklahoma, with 21 deaths recorded in total. An F4 tornado was detected by a mobile doppler weather radar team which observed winds up to 270 mph (430 km/h) at the top of the funnel, the first time winds of F5 intensity were measured by radar, and the highest winds recorded by radar at the time. A news team filming an F2 tornado sought shelter under a Kansas Turnpike overpass, causing a misconception that overpasses can provide adequate shelter during a tornado. This outbreak occurred within a transition period for the National Weather Service and proved the value of NEXRAD radars, which were utilized in Oklahoma to provide advanced warning to residents.

The Central United States is sometimes conceived as between the Eastern and Western as part of a three-region model, roughly coincident with the U.S. Census Bureau's definition of the Midwestern United States plus the western and central portions of the U.S. Census's definition of the Southern United States. The Central States are typically considered to consist of North Dakota, South Dakota, Nebraska, Kansas, Oklahoma, Texas, Minnesota, Iowa, Missouri, Arkansas, Louisiana, Wisconsin, Illinois, Michigan, Indiana, Ohio, Kentucky, Tennessee, West Virginia, Mississippi and Alabama.

Andover is a city in Butler County, Kansas, United States, and a suburb of Wichita. As of the 2020 census, the population of the city was 14,892. Andover is the most populated city in Butler County.