First Barbary War: United States Marines and Berbers attack the Tripolitan city of Derna (The "shores of Tripoli" in the Marines' Hymn).

The First Barbary War (1801–1805), also known as the Tripolitan War and the Barbary Coast War, was a conflict during the 1801–1815 Barbary Wars, in which the United States fought against Ottoman Tripolitania. Tripolitania had declared war against the United States over disputes regarding tributary payments in exchange for a cessation of Tripolitanian commerce raiding at sea. United States President Thomas Jefferson refused to pay this tribute. The First Barbary War was the first major American war fought outside the New World, and in the Arab world, besides the smaller American–Algerian War (1785–1795).

The United States Marine Corps (USMC), also referred to as the United States Marines or simply the Marines, is the maritime land force service branch of the United States Department of Defense. It is responsible for conducting expeditionary and amphibious operations through combined arms, implementing its own infantry, artillery, aerial, and special operations forces. The U.S. Marine Corps is one of the six armed forces of the United States and one of the eight uniformed services of the United States.

Berbers, or the Berber peoples, also known as Amazigh or Imazighen, are a diverse grouping of distinct ethnic groups indigenous to North Africa who predate the arrival of Arabs in the Maghreb. Their main connections are identified by their usage of Berber languages, most of them mutually unintelligible, which are part of the Afroasiatic language family.

Tripoli, historically known as Tripoli-of-the-West, is the capital and largest city of Libya, with a population of about 1.317 million people in 2021. It is located in the northwest of Libya on the edge of the desert, on a point of rocky land projecting into the Mediterranean Sea and forming a bay. It includes the port of Tripoli and the country's largest commercial and manufacturing center. It is also the site of the University of Tripoli.