Prime Minister Milton Margai led the Sierra Leone Colony and Protectorate to independence from the United Kingdom.

Sir Milton Augustus Strieby Margai was a Sierra Leonean physician and politician who served as the country's head of government from 1954 until his death in 1964. He was titled chief minister from 1954 to 1960, and then prime minister from 1961 onwards. Margai studied medicine in England, and upon returning to his homeland became a prominent public health campaigner. He entered politics as the founder and inaugural leader of the Sierra Leone People's Party. Margai oversaw Sierra Leone's transition to independence, which occurred in 1961. He died in office aged 68, and was succeeded as prime minister by his brother Albert. Margai enjoyed the support of Sierra Leoneans across classes, who respected his moderate style, friendly demeanor, and political savvy.

The Colony and Protectorate of Sierra Leone was the British colonial administration in Sierra Leone from 1808 to 1961, part of the British Empire from the abolitionism era until the decolonisation era. The Crown colony, which included the area surrounding Freetown, was established in 1808. The protectorate was established in 1896 and included the interior of what is today known as Sierra Leone.