A powerful explosion occurs in an office building in Prague, believed to have been caused by natural gas, and injures 43 people.

On April 29, 2013 at around 10:00am CEST, an explosion occurred in a building in the centre of Prague, Czech Republic. The incident occurred in a townhouse belonging to the Air Navigation Services of the Czech Republic on Divadelní street in Old Town, Prague 1, close to the Academy of Sciences and National Theatre. The blast could be heard across the whole city centre, as far away as Prague Castle, 1.4 km (1 mi) away from the incident. While there were no fatalities, 43 people were injured by the blast, one seriously. The resulting shock wave from the blast damaged windows in nearby buildings including the National Theatre, Café Slavia, the Film and TV School of the Academy of Performing Arts in Prague (FAMU), the Faculty of Social Sciences of Charles University and the Academy of Sciences of the Czech Republic.

Prague is the capital and largest city of the Czech Republic and the historical capital of Bohemia. Prague, located on the Vltava River, has a population of about 1.4 million, while its metropolitan area is home to approximately 2.3 million people.

April 29 is the 119th day of the year in the Gregorian calendar; 246 days remain until the end of the year.