Henry II of France and Philip II of Spain signed the second treaty of Cateau-Cambrésis, ending the Italian War of 1551–1559.

Henry II was King of France from 1547 until his death in 1559. The second son of Francis I and Claude, Duchess of Brittany, he became Dauphin of France upon the death of his elder brother Francis in 1536.

Philip II, sometimes known in Spain as Philip the Prudent, was King of Spain from 1556, King of Portugal from 1580, and King of Naples and Sicily from 1554 until his death in 1598. He was also jure uxoris King of England and Ireland from his marriage to Queen Mary I in 1554 until her death in 1558. Further, he was Duke of Milan from 1540. From 1555, he was Lord of the Seventeen Provinces of the Netherlands.

The Treaty of Cateau-Cambrésis in April 1559 ended the Italian Wars (1494–1559). It consisted of two separate treaties, one between England and France on 2 April, and another between France and Spain on 3 April. Although he was not a signatory, both were approved by Emperor Ferdinand I, since many of the territorial exchanges concerned states within the Holy Roman Empire.

The Italian War of 1551–1559 began when Henry II of France declared war against Holy Roman Emperor Charles V with the intent of recapturing parts of Italy and ensuring French, rather than Habsburg, domination of European affairs. The war ended following the signing of the Treaty of Cateau-Cambrésis between the monarchs of Spain, England and France in 1559. Historians have emphasized the importance of gunpowder technology, new styles of fortification to resist cannon fire, and the increased professionalization of the soldiers.