Francis Xavier leaves Lisbon on a mission to the Portuguese East Indies.

Francis Xavier,, venerated as Saint Francis Xavier, was a Navarrese cleric and missionary. He co-founded the Society of Jesus and, as a representative of the Portuguese Empire, led the first Christian mission to Japan.

Lisbon is the capital and largest city of Portugal, with an estimated population of 575,739, as of 2024, within its administrative limits and 3,028,000 within the metropolis, as of 2025. Lisbon is mainland Europe's westernmost capital city, and the only one along the Atlantic coast, the others being on islands. The city lies in the western portion of the Iberian Peninsula, on the northern shore of the River Tagus. The western portion of its metro area, the Portuguese Riviera, hosts the westernmost point of Continental Europe, culminating at Cabo da Roca.

The Portuguese Empire was a colonial empire that existed between 1415 and 1999. In conjunction with the Spanish Empire, it ushered in the European Age of Discovery. It achieved a global scale, controlling vast portions of the Americas, Africa and various islands in Asia and Oceania. It was one of the most powerful empires of the early modern period, while at its greatest extent in 1820, covering 5.5 million square km, making it among the largest empires in history. Composed of colonies, factories, and later overseas territories, it was the longest-lived colonial empire in history, from the conquest of Ceuta in North Africa in 1415 to the handover of Macau to China in 1999.

April 7 is the 97th day of the year in the Gregorian calendar; 268 days remain until the end of the year.