The naval Battle of Saint-Mathieu, during the War of the League of Cambrai, sees the simultaneous destruction of the Breton ship La Cordelière and the English ship The Regent.

The Battle of Saint-Mathieu took place on 10 August 1512 during the War of the League of Cambrai, near Brest, France, between an English fleet of 25 ships commanded by Sir Edward Howard and a Franco-Breton fleet of 22 ships commanded by René de Clermont. It is possibly the first battle between ships using cannon through ports, although this played a minor role in the fighting. This was one of only two full-fledged naval battles fought by King Henry VIII's Tudor navy, along with the later Battle of the Solent. During the battle, each navy's largest and most powerful ship — Regent and the Marie-la-Cordelière – were destroyed in a large explosion aboard the latter.

The War of the League of Cambrai, also known by its second stage as the War of the Holy League, was fought from February 1508 to December 1516, as part of the wider Italian Wars of 1494–1559. The main participants of the war, who fought for its entire duration, were France, the Papal States, and the Republic of Venice; they were joined at various times by nearly every significant power in Western Europe, including the Holy Roman Empire, Spain, England, the Duchy of Milan, the Republic of Florence, the Duchy of Ferrara, and the Swiss.