William Cavendish, 1st Duke of Devonshire, English soldier and politician, Lord Lieutenant of Derbyshire (born 1640)

William Cavendish, 1st Duke of Devonshire was an English Whig politician who sat in the House of Commons of England from 1661 until 1684 when he inherited his father's peerage as Earl of Devonshire and took his seat in the House of Lords. Cavendish was part of the "Immortal Seven" which invited William of Orange to depose James II of England as part of the Glorious Revolution, and was rewarded for his efforts by being elevated to the Duke of Devonshire in 1694.

This is a list of people who have served as Lord Lieutenant of Derbyshire. Since 1689, all the Lord Lieutenants have also been Custos Rotulorum of Derbyshire.