Francisco de Orellana crosses South America from Guayaquil on the Pacific coast to the mouth of the Amazon River on the Atlantic coast.

Francisco de Orellana was a Spanish explorer and conquistador. In one of the most improbably successful voyages in known history, Orellana managed to sail the length of the Amazon, arriving at the river's mouth on 24 August 1542. He and his party sailed along the Atlantic coast until reaching Cubagua Island, near the coast of Venezuela.