The first Lutheran denomination in North America, the Pennsylvania Ministerium, was founded in Philadelphia.

Lutheranism is a major branch of Protestantism that emerged under the work of Martin Luther, the 16th-century German friar and reformer whose efforts to reform the theology and practices of the Catholic Church launched the Reformation in 1517. The Lutheran Churches adhere to the Bible and the Ecumenical Creeds, with Lutheran doctrine being explicated in the Book of Concord. Lutherans hold themselves to be in continuity with the apostolic church and affirm the writings of the Church Fathers and the first four ecumenical councils.

The Pennsylvania Ministerium was the first Lutheran church body in North America. With the encouragement of Henry Melchior Muhlenberg (1711–1787), the Ministerium was founded at a Church Conference of Lutheran clergy on August 26, 1748. The group was known as the "German Evangelical Lutheran Ministerium of North America" until 1792, when it adopted the name "German Evangelical Lutheran Ministerium of Pennsylvania and Adjacent States".