Comair Flight 5191 crashes on takeoff from Blue Grass Airport in Lexington, Kentucky, bound for Hartsfield–Jackson Atlanta International Airport in Atlanta. Of the passengers and crew, 49 of 50 are confirmed dead in the hours following the crash.

Comair Flight 5191 was a scheduled United States domestic passenger flight from Lexington, Kentucky, to Atlanta, Georgia. On the morning of August 27, 2006, at around 06:07 EDT, the Bombardier CRJ100ER crashed while attempting to take off from Blue Grass Airport in Fayette County, Kentucky, 4 miles west of the central business district of the city of Lexington.

Takeoff is the phase of flight in which an aerospace vehicle leaves the ground and becomes airborne. For aircraft traveling vertically, this is known as liftoff.

Blue Grass Airport is a public airport in Fayette County, Kentucky, United States, 6 miles west of downtown Lexington. Located among horse farms and situated directly across from Keeneland Race Course, Blue Grass Airport is the primary airport serving central and eastern Kentucky. More than 1.3 million passengers depart or arrive annually at Blue Grass Airport. In 2017, the airport served 1,316,847 passengers via four major airline carriers: Allegiant Air, American Airlines, Delta Air Lines, and United Airlines.

Lexington is a consolidated city coterminous with Fayette County, Kentucky, United States, of which it is also the county seat. As of the 2020 census the city's population was 322,570, making it the second-most populous city in Kentucky, the 14th-most populous city in the Southeast, and the 59th-most populous city in the United States. By area, it is the country's 33rd-largest city.

Hartsfield–Jackson Atlanta International Airport is the primary international airport serving Atlanta and its surrounding metropolitan area in the U.S. state of Georgia. It is located 10 mi south of the Downtown Atlanta district, and it is named after former Atlanta mayors William B. Hartsfield and Maynard Jackson.