Second Fitna: Pro-Alid forces defeated the Umayyad Caliphate in the Battle of Khazir, allowing them to take control of Mosul in present-day Iraq.

The Second Fitna was a period of general political and military disorder and civil war in the Islamic community during the early Umayyad Caliphate. It followed the death of the first Umayyad caliph Mu'awiya I in 680, and lasted for about twelve years. The war involved the suppression of two challenges to the Umayyad dynasty, the first by Husayn ibn Ali, as well as his supporters including Sulayman ibn Surad and Mukhtar al-Thaqafi who rallied for his revenge in Iraq, and the second by Abd Allah ibn al-Zubayr.

The Alids are those who claim descent from Ali ibn Abi Talib, the fourth Rashidun caliph and the first imam in Shia Islam. Ali was also the cousin and son-in-law of the Islamic prophet Muhammad. The main branches are the Hasanids and Husaynids, named after Hasan and Husayn, the eldest sons of Ali from his marriage to Fatima, the daughter of Muhammad. As the progeny of Muhammad, they are revered by all Muslims. The Alids have led various movements in Islam, and a line of twelve Alids are the imams in Twelver Shia, the largest Shia branch.

The Umayyad Caliphate or Umayyad Empire was the second caliphate established after the death of the Islamic prophet Muhammad and was ruled by the Umayyad dynasty. Uthman ibn Affan, the third of the Rashidun caliphs, was also a member of the clan. The family established dynastic, hereditary rule with Mu'awiya I, the long-time governor of Greater Syria, who became caliph after the end of the First Fitna in 661. After Mu'awiya's death in 680, conflicts over the succession resulted in the Second Fitna, and power eventually fell to Marwan I, from another branch of the clan. Syria remained the Umayyads' main power base thereafter, with Damascus as their capital.

The Battle of Khazir took place in August 686 near the Khazir River in Mosul's eastern environs, in modern-day Iraq. The battle occurred during the Second Muslim Civil War and was part of the larger struggle for control of Iraq between the Syria-based Umayyad Caliphate, the Kufa-based pro-Alid forces of Mukhtar al-Thaqafi, and the Mecca-based caliphate of Abd Allah ibn al-Zubayr. It ended with the Umayyads being routed and the expansion of Mukhtar's rule into the region of Mosul.