Four hundred Shawnee people agree to relinquish their lands in Ohio in exchange for land west of the Mississippi River in the Treaty of Wapakoneta.

The Shawnee are a Native American people of the Northeastern Woodlands. Their language, Shawnee, is an Algonquian language.

Ohio is a state in the Midwestern region of the United States. It borders Lake Erie to the north, Pennsylvania to the east, West Virginia to the southeast, Kentucky to the southwest, Indiana to the west, and Michigan to the northwest. Of the 50 U.S. states, it is the 34th-largest by area. With a population of nearly 11.9 million, Ohio is the seventh-most populous and tenth-most densely populated state. Its capital and most populous city is Columbus, with other major metropolitan centers including Cleveland and Cincinnati, as well as Dayton, Akron, and Toledo. Ohio is nicknamed the "Buckeye State" after its Ohio buckeye trees, and Ohioans are also known as "Buckeyes".

The Mississippi River is the primary river of the largest drainage basin in the United States. It is the second-longest river in the United States, behind only the Missouri. From its traditional source of Lake Itasca in northern Minnesota, it flows generally south for 2,340 mi (3,770 km) to the Mississippi River Delta in the Gulf of Mexico. With its many tributaries, the Mississippi's watershed drains all or parts of 32 U.S. states and two Canadian provinces between the Rocky and Appalachian mountains. The river either borders or passes through the states of Minnesota, Wisconsin, Iowa, Illinois, Missouri, Kentucky, Tennessee, Arkansas, Mississippi, and Louisiana. The main stem is entirely within the United States; the total drainage basin is 1,151,000 sq mi (2,980,000 km²), of which only about one percent is in Canada. The Mississippi ranks as the world's tenth-largest river by discharge flow, and the largest in North America.

The Treaty of Wapakoneta was signed on August 8, 1831. Remnants of the Shawnee Native American tribe in Wapakoneta were forced to relinquish claims that they had to land in western Ohio.