The First Anglo-Powhatan War begins in colonial Virginia.

The Anglo–Powhatan Wars were three wars fought between settlers of the Colony of Virginia and the Powhatan People of Tsenacommacah in the early 17th century. The first war started in 1609 and ended in a peace settlement in 1614. The second war lasted from 1622 to 1632. The third war lasted from 1644 until 1646 and ended when Opechancanough was captured and killed. That war resulted in a defined boundary between the Native Americans and colonial lands that could only be crossed for official business with a special pass. This situation lasted until 1677 and the Treaty of Middle Plantation which established Indian reservations following Bacon's Rebellion.

The Colony of Virginia was a British colonial settlement in North America from 1606 to 1776.