Siege of Rome: The Ostrogoths under king Totila plunder the city, by bribing the Eastern Roman garrison.

The sack of Rome in 546 was carried out by the Gothic king Totila during the Gothic War of 535–554 between the Ostrogoths and the Eastern Roman Empire. Totila was based at Tivoli and, in pursuit of his quest to reconquer the region of Latium, he moved against Rome. The city endured a siege lasting almost a year before falling to the Goths.

The Ostrogoths were a Roman-era Germanic people. In the 5th century, they followed the Visigoths in creating one of the two great Gothic kingdoms within the Western Roman Empire, drawing upon the large Gothic populations who had settled in the Balkans in the 4th century. While the Visigoths had formed under the leadership of Alaric I, the new Ostrogothic political entity which came to rule Italy was formed in the Balkans under Theodoric the Great.

Totila, original name Baduila, was the penultimate King of the Ostrogoths, reigning from 541 to 552 AD. A skilled military and political leader, Totila reversed the tide of the Gothic War, recovering by 543 almost all the territories in Italy that the Eastern Roman Empire had captured from his Kingdom in 540.

The Byzantine Empire, also known as the Eastern Roman Empire, was the continuation of the Roman Empire centred on Constantinople during late antiquity and the Middle Ages. Having survived the events that caused the fall of the Western Roman Empire in the 5th century AD, it endured until the fall of Constantinople to the Ottoman Empire in 1453. The term 'Byzantine Empire' was coined only after its demise; its citizens used the term 'Roman Empire' and called themselves 'Romans'.