Vice President of the United States John C. Calhoun sparks the Nullification Crisis when he anonymously publishes the South Carolina Exposition and Protest, protesting the Tariff of 1828.

The vice president of the United States is the second-highest ranking office in the executive branch of the U.S. federal government, after the president of the United States, and ranks first in the presidential line of succession. The vice president is also an officer in the legislative branch, as the president of the Senate. In this capacity, the vice president is empowered to preside over the United States Senate, but may not vote except to cast a tie-breaking vote. The vice president is indirectly elected at the same time as the president to a four-year term of office by the people of the United States through the Electoral College, but the electoral votes are cast separately for these two offices. Following the passage in 1967 of the Twenty-fifth Amendment to the US Constitution, a vacancy in the office of vice president may be filled by presidential nomination and confirmation by a majority vote in both houses of Congress.

John Caldwell Calhoun was an American statesman and political theorist who served as the seventh vice president of the United States from 1825 to 1832. Born in South Carolina, Calhoun began his political career as a nationalist, modernizer and proponent of a strong federal government and protective tariffs. In the late 1820s, his views shifted, and he became a leading proponent of states' rights, limited government, nullification, and opposition to high tariffs, and distinguished himself as an outspoken defender of American slavery. Calhoun saw Northern acceptance of those policies as a condition of the South's remaining in the Union. His beliefs heavily influenced the South's secession from the Union in 1860 and 1861. Calhoun was the first of two vice presidents to resign from the position, the second being Spiro Agnew, who resigned in 1973.

The nullification crisis was a sectional political crisis in the United States in 1832 and 1833, during the presidency of Andrew Jackson, which involved a confrontation between the state of South Carolina and the federal government. It ensued after South Carolina declared the federal Tariffs of 1828 and 1832 unconstitutional and therefore null and void within the sovereign boundaries of the state.