World War II: During the Manhattan Project, a team led by Enrico Fermi initiates the first artificial self-sustaining nuclear chain reaction.

World War II or the Second World War was a global conflict between two coalitions: the Allies and the Axis powers. Nearly all of the world's countries participated, with many nations mobilising all resources in pursuit of total war. Tanks and aircraft played major roles, enabling the strategic bombing of cities and delivery of the first and only nuclear weapons ever used in war. World War II is the deadliest conflict in history, causing the death of 70 to 85 million people, more than half of whom were civilians. Millions died in genocides, including the Holocaust, and by massacres, starvation, and disease. After the Allied victory, Germany, Austria, Japan, and Korea were occupied, and German and Japanese leaders were tried for war crimes.

The Manhattan Project was a research and development program undertaken during World War II to produce the first nuclear weapons. It was led by the United States in collaboration with the United Kingdom and Canada.

Enrico Fermi was an Italian and naturalized American physicist, renowned for being the creator of the world's first artificial nuclear reactor, the Chicago Pile-1, and a member of the Manhattan Project. He has been called the "architect of the nuclear age" and the "architect of the atomic bomb". He was one of very few physicists to excel in both theoretical and experimental physics. Fermi was awarded the 1938 Nobel Prize in Physics for his work on induced radioactivity by neutron bombardment and for the discovery of transuranium elements. With his colleagues, Fermi filed several patents related to the use of nuclear power, all of which were taken over by the US government. He made significant contributions to the development of statistical mechanics, quantum theory, and nuclear and particle physics.

Chicago Pile-1 (CP-1) was the first artificial nuclear reactor. On 2 December 1942, the first human-made self-sustaining nuclear chain reaction was initiated in CP-1 during an experiment led by Enrico Fermi. The secret development of the reactor was the first major technical achievement for the Manhattan Project, the Allied effort to create nuclear weapons during World War II. Developed by the Metallurgical Laboratory at the University of Chicago, CP-1 was built under the west viewing stands of the original Stagg Field. Although the project's civilian and military leaders had misgivings about the possibility of a disastrous runaway reaction, they trusted Fermi's safety calculations and decided they could carry out the experiment in a densely populated area. Fermi described the reactor as "a crude pile of black bricks and wooden timbers".