Settlers from the United States in Mexican Texas made the first attempt to secede from Mexico, establishing the short-lived Republic of Fredonia.

Mexican Texas is the historiographical name used to refer to the era of Texan history between 1821 and 1836, when it was part of Mexico. Mexico gained independence in 1821 after winning its war against Spain, which began in 1810. Initially, Mexican Texas operated similarly to Spanish Texas. Ratification of the 1824 Constitution of Mexico created a federal structure, and the province of Tejas was joined with the province of Coahuila to form the state of Coahuila y Tejas.

The Fredonian Rebellion or Texan revolt of 1826 was the first attempt by Texans to secede from Mexico. The settlers, led by Empresario Haden Edwards, declared independence from Mexican Texas and created the Republic of Fredonia near Nacogdoches. The short-lived republic encompassed the land the Mexican government had granted to Edwards in 1825 and included areas that had been previously settled. Edwards's actions soon alienated the established residents, and the increasing hostilities between them and settlers recruited by Edwards led Víctor Blanco of the Mexican government to revoke Edwards's contract.