First successful kidney transplant is performed by J. Hartwell Harrison and Joseph Murray.

Kidney transplant or renal transplant is the organ transplant of a kidney into a patient with end-stage kidney disease (ESRD). Kidney transplant is typically classified as deceased-donor or living-donor transplantation depending on the source of the donor organ. Living-donor kidney transplants are further characterized as genetically related (living-related) or non-related (living-unrelated) transplants, depending on whether a biological relationship exists between the donor and recipient. The first successful kidney transplant was performed in 1954 by a team including Joseph Murray, the recipient's surgeon, and Hartwell Harrison, surgeon for the donor. Murray was awarded a Nobel Prize in Physiology or Medicine in 1990 for this and other work. In 2018, an estimated 95,479 kidney transplants were performed worldwide, 36% of which came from living donors.

John Hartwell Harrison was an American urologic surgeon, professor, and author. He performed the first human organ removal for transplant to another. This was a pivotal undertaking as a member of the medical team that accomplished the world’s first successful kidney transplant. The team conducted its landmark transplant between identical twins in 1954.

Joseph Edward Murray was an American plastic surgeon who is known as the "father of transplantation" for major milestones in the field of transplantation, including performing the first successful human kidney transplant, defining brain death, organizing the first international conference on human kidney transplants, and founding the National Kidney Registry, the forerunner of the current United Network of Organ Sharing (UNOS). As of 2013, more than one million patients were estimated to have benefitted from organ transplantation around the world.