A railway bridge collapsed over the Ashtabula River in Ohio, killing 92 people and injuring 64 others on a Lake Shore and Michigan Southern Railway train.

The Ashtabula River railroad disaster was caused by the collapse of a bridge over the Ashtabula River near the town of Ashtabula, Ohio, in the United States on Friday, December 29, 1876. A train of the Lake Shore and Michigan Southern Railway, named the Pacific Express, was passing over the bridge as it collapsed, falling into the icy river. All but the lead locomotive plunged into the river. The train's oil lanterns and coal-fired heating stoves set the wooden cars alight. Firefighters declined to extinguish the flames, leaving individuals to try to pull survivors from the wreck. Many who survived the crash burned to death in the wreckage. The accident killed approximately 92 of the 160 people aboard. It was the worst rail accident in the U.S. in the 19th century and the worst rail accident in U.S. history until the Great Train Wreck of 1918. It remains the third-deadliest rail accident in U.S. history.

The Ashtabula River is a river located northeast of Cleveland in Ohio. The river flows into Lake Erie at the city of Ashtabula, Ohio. It is 40 miles (64 km) in length and drains 137 square miles (350 km²).

Ohio is a state in the Midwestern region of the United States. It borders Lake Erie to the north, Pennsylvania to the east, West Virginia to the southeast, Kentucky to the southwest, Indiana to the west, and Michigan to the northwest. Of the 50 U.S. states, it is the 34th-largest by area. With a population of nearly 11.9 million, Ohio is the seventh-most populous and tenth-most densely populated state. Its capital and most populous city is Columbus, with other major metropolitan centers including Cleveland and Cincinnati, as well as Dayton, Akron, and Toledo. Ohio is nicknamed the "Buckeye State" after its Ohio buckeye trees, and Ohioans are also known as "Buckeyes".