Tornadoes touch down in midwestern and southern United States, including Washington County, Arkansas; Greater St. Louis, Sunset Hills, Missouri, Illinois, and Oklahoma, with a few tornadoes in the early hours. A total of 36 tornadoes touched down, resulting in the deaths of nine people and $113 million in damages.

A destructive and deadly three-day-long tornado outbreak impacted the central and lower Mississippi Valley from December 30, 2010, to January 1, 2011. Associated with a low pressure system and a strong cold front, 37 tornadoes tracked across five states over the length of the severe event, killing nine and injuring several others. Activity was centered in the states of Missouri and later Mississippi on December 31. Seven tornadoes were rated EF3 on the Enhanced Fujita Scale; these were the strongest during the outbreak. Non-tornadic winds were recorded to have reached as high as 80 mph (130 km/h) at eight locations on December 31, while hail as large as 2.75 in (7.0 cm) was documented north-northeast of Mansfield, Missouri. Overall, damage from the outbreak totaled US$123.3 million, most of which was related to tornadoes. This is the most prolific tornado outbreak in Missouri in the month of December.

The Midwestern United States is one of the four census regions defined by the United States Census Bureau. It occupies the northern central part of the United States. It was officially named the North Central Region by the U.S. Census Bureau until 1984. It is between the Northeastern United States and the Western United States, with Canada to the north and the Southern United States to the south.

The Southern United States is one of the four census regions defined by the United States Census Bureau. It is between the Atlantic Ocean and the Western United States, with the Midwestern and Northeastern United States to its north and the Gulf of Mexico and Mexico to its south.

Washington County is a regional economic, educational, and cultural hub in the Northwest Arkansas region. Created as Arkansas's 17th county on November 30, 1848, Washington County has 13 incorporated municipalities, including Fayetteville, the county seat, and Springdale. The county is also the site of small towns, bedroom communities, and unincorporated places. The county is named for George Washington, the first President of the United States. Located within the Ozark Mountains, the county is roughly divided into two halves: the rolling Springfield Plateau in the more populous north of the county and the steeper, forested Boston Mountains in the much less populated south. It contains three segments of the Ozark National Forest, two state parks, two Wildlife Management Areas, the Garrett Hollow Natural Area, and dozens of city parks. Other historical features such as Civil War battlefields, log cabins, one-room school houses, community centers, and museums describe the history and culture of Washington County. Washington County occupies 951.72 square miles and contained a population of 245,871 people in 89,249 households as of the 2020 Census, ranking it 4th in size and 3rd in population among the state's 75 counties. The economy is largely based on the business/management, education, sales, office/administration, and poultry production industries. Poverty rates, median household income, and unemployment rates best state averages, but lag national trends. Washington County has long had a reputation for education in the state. The University of Arkansas, the largest four-year college in the state, was established in Fayetteville in 1871. A Washington County campus of the Northwest Arkansas Community College was opened in 2019 in Springdale. Today, Washington County contains eight public school districts, including two of the largest districts in the state and two private schools. It is included in the Fayetteville–Springdale–Rogers Metropolitan Statistical Area.