Alpha Phi Alpha the first intercollegiate Greek lettered fraternity for African-Americans was founded at Cornell University in Ithaca, New York.

Alpha Phi Alpha Fraternity, Inc. (ΑΦΑ) is the oldest intercollegiate historically African American fraternity. It was initially a literary and social studies club organized in the 1905–1906 school year at Cornell University but later evolved into a fraternity with a founding date of December 4, 1906. It employs an icon from Ancient Egypt, the Great Sphinx of Giza, as its symbol. Its aims or pillars are "Manly Deeds, Scholarship, and Love For All Mankind," and its motto is "First of All, Servants of All, We Shall Transcend All." Its archives are preserved at the Moorland-Spingarn Research Center.

Cornell University is a private Ivy League research university based in Ithaca, New York, United States. The university was co-founded by American philanthropist Ezra Cornell and historian and educator Andrew Dickson White in 1865. Since its founding, Cornell University has been a co-educational and nonsectarian institution. As of fall 2024, the student body included 16,128 undergraduate and 10,665 graduate students from all 50 U.S. states and 130 countries.

Ithaca is a city in and the county seat of Tompkins County, New York, United States. Situated on the southern shore of Cayuga Lake in the Finger Lakes region of New York, Ithaca is the largest community in the Ithaca metropolitan statistical area. It is named after the Greek island of Ithaca. As of 2020, the city's population was 32,108.