Just before it was scheduled to land at Buffalo Niagara International Airport, Colgan Air Flight 3407 crashed into a house in Clarence Center, New York, killing the house's occupant and all 49 people on board the aircraft.

Buffalo Niagara International Airport is in Cheektowaga, New York, United States. The airport serves Buffalo, New York and Niagara Falls, New York in the United States, and the southern Golden Horseshoe region of Ontario, Canada. It is the third-busiest airport in the state of New York and the busiest inside of the Buffalo-Niagara Falls metropolitan area. It is about 11 miles (18 km) east of Downtown Buffalo and 60 miles (97 km) southeast of Toronto. The airport covers 1,000 acres (400 ha).

Colgan Air Flight 3407 was a scheduled passenger flight from Newark, New Jersey, to Buffalo, New York, on February 12, 2009. Approaching Buffalo, the aircraft, a Bombardier Q400, entered an aerodynamic stall from which it did not recover and crashed into a house at 6038 Long Street in Clarence Center, New York, at 10:17 pm EST, about 5 miles from the end of the runway, killing all 49 passengers and crew on board and one person inside the house.

Clarence Center is an affluent hamlet and census-designated place (CDP) in the town of Clarence in Erie County, New York, United States. The population was 3,337 as of 2021. It is part of the Buffalo–Niagara Falls Metropolitan Statistical Area.