NASA's first Space Shuttle, Enterprise, made its first test flight on top of the Shuttle Carrier Aircraft (both pictured).

The National Aeronautics and Space Administration is an independent agency of the US federal government responsible for the United States's civil space program, aeronautics research and space research. Established in 1958, it succeeded the National Advisory Committee for Aeronautics (NACA) to give the American space development effort a distinct civilian orientation, emphasizing peaceful applications in space science. It has since led most of America's space exploration programs, including Project Mercury, Project Gemini, the 1968–1972 Apollo program missions, the Skylab space station, and the Space Shuttle. Currently, NASA supports the International Space Station (ISS) along with the Commercial Crew Program and oversees the development of the Orion spacecraft and the Space Launch System for the lunar Artemis program.

The Space Shuttle program was the fourth human spaceflight program carried out by the U.S. National Aeronautics and Space Administration (NASA), which accomplished routine transportation for Earth-to-orbit crew and cargo from 1981 to 2011. Its official program name was Space Transportation System (STS), taken from a 1969 plan for a system of reusable spacecraft where it was the only item funded for development, as a proposed nuclear shuttle in the plan was cancelled in 1972. It flew 135 missions and carried 355 astronauts from 16 countries, many on multiple trips.

Space Shuttle Enterprise was the first orbiter of the Space Shuttle system. Rolled out on September 17, 1976, it was built for NASA as part of the Space Shuttle program to perform atmospheric test flights after being launched from a modified Boeing 747. It was constructed without engines or a functional heat shield. As a result, it was not capable of spaceflight.

The Shuttle Carrier Aircraft (SCA) are two extensively modified Boeing 747 airliners that NASA used to transport Space Shuttle orbiters. One (N905NA) is a 747-100 model, while the other (N911NA) is a short-range 747-100SR. Both are now retired.