35 children and 1 adult employee were killed in a fire at an orphanage in the town of Cavan, Ireland.

The Cavan Orphanage fire occurred on the night of 23 February 1943 at St Joseph's Orphanage in Cavan, Ireland. 35 children and one adult employee died as a result. All of the lay teachers and nuns survived the fire. Much of the attention after the fire surrounded the role of the Poor Clares, the order of nuns who ran the orphanage, and the local fire service.

Cavan is the county town of County Cavan in Ireland. The town lies in Ulster, near the border with County Fermanagh in Northern Ireland. The town is bypassed by the main N3 road that links Dublin with Enniskillen, Ballyshannon and Donegal Town.

Ireland is an island in the North Atlantic Ocean, in Northwestern Europe. Geopolitically, the island is divided between the Republic of Ireland and Northern Ireland. It is separated from Great Britain to its east by the North Channel, the Irish Sea, and St George's Channel. Ireland is the second-largest island of the British Isles, the third-largest in Europe, and the twentieth-largest in the world. As of 2022, the population of the entire island is just over 7 million, with 5.1 million in the Republic of Ireland and 1.9 million in Northern Ireland, ranking it the second-most populous island in Europe after Great Britain.