Manuel Noriega is indicted on drug smuggling and money laundering charges.

Manuel Antonio Noriega Moreno was a Panamanian dictator and military officer who was the de facto ruler of Panama from 1983 to 1989. He never officially served as president of Panama, instead ruling as an unelected military dictator through puppet presidents. Amassing a personal fortune through drug trafficking operations by the Panamanian military, Noriega had longstanding ties with American intelligence agencies before the U.S. invasion of Panama removed him from power.

The illegal drug trade, drug trafficking, or narcotrafficking is a global black market dedicated to the cultivation, manufacture, distribution and sale of prohibited drugs. Most jurisdictions prohibit trade, except under license, of many types of drugs through the use of drug prohibition laws. The think tank Global Financial Integrity's Transnational Crime and the Developing World report estimates the size of the global illicit drug market between US$426 and US$652 billion in 2014. With a world GDP of US$78 trillion in the same year, the illegal drug trade may be estimated as nearly 1% of total global trade. Consumption of illegal drugs is widespread globally, and it remains very difficult for local authorities to reduce the rates of drug consumption.

Money laundering is the process of illegally concealing the origin of money obtained from illicit activities such as drug trafficking, sex work, terrorism, corruption, and embezzlement, and converting the funds into a seemingly legitimate source, usually through a front organization. Money laundering is ipso facto illegal; the acts generating the money almost always are themselves criminal in some way. As financial crime has become more complex and financial intelligence is more important in combating international crime and terrorism, money laundering has become a prominent political, economic, and legal debate. Most countries implement some anti-money-laundering measures.