Birgenair Flight 301 crashed off the coast of the Dominican Republic, killing all 189 people on board. This is the deadliest aviation accident involving a Boeing 757.

Birgenair Flight 301 was a flight chartered by Turkish-managed Birgenair partner Alas Nacionales from Puerto Plata in the Dominican Republic to Frankfurt, Germany, via Gander, Canada, and Berlin, Germany. On 6 February 1996, the Boeing 757-200 operating the route crashed shortly after take-off from Puerto Plata's Gregorio Luperón International Airport, killing all 189 people on board. The cause was pilot error after receiving incorrect airspeed information from one of the pitot tubes, which investigators believe was blocked by a wasp nest built inside it. The aircraft had been sitting unused for 20 days, and without pitot tube covers in place for the two days preceding the crash.

The Dominican Republic is a country in the Caribbean located on the island of Hispaniola in the Greater Antilles of the Caribbean Sea in the North Atlantic Ocean. It shares a maritime border with Puerto Rico to the east and a land border with Haiti to the west, occupying the eastern five-eighths of Hispaniola which, along with Saint Martin, is one of only two islands in the Caribbean shared by two sovereign states. In the Antilles, the country is the second-largest nation by area after Cuba at 48,671 square kilometers (18,792 sq mi) and second-largest by population after Haiti with approximately 11.4 million people in 2024, of whom 3.6 million reside in the metropolitan area of Santo Domingo, the capital city.

The Boeing 757 is an American narrow-body airliner designed and built by Boeing Commercial Airplanes. The then-named 7N7, a twinjet successor for the trijet 727, received its first orders in August 1978. The prototype completed its maiden flight on February 19, 1982, and it was FAA certified on December 21, 1982. Eastern Air Lines placed the initial 757-200 variant in commercial service on January 1, 1983. A package freighter (PF) variant entered service in September 1987 and a combi model in September 1988. The stretched 757-300 was launched in September 1996 and began service in March 1999. After 1,050 had been built for 54 customers, production ended in October 2004, while Boeing offered the largest 737 Next Generation variants as a successor to the -200.