The first ship of the American Colonization Society departed from New York for West Africa with 86 African-American emigrants aboard to found the colony of Liberia.

The American Colonization Society (ACS), initially the Society for the Colonization of Free People of Color of America, was an American organization founded in 1816 by Robert Finley to encourage and support the repatriation of freeborn people of color and emancipated slaves to the continent of Africa. It was modeled on an earlier British Committee for the Relief of the Black Poor's colonization in Africa, which had sought to resettle London's "black poor". Until the organization's dissolution in 1964, the society was headquartered in Room 516 of the Colorado Building in Washington, D.C.

Liberia is a country in West Africa founded by free people of color from the United States. The emigration of African Americans, both freeborn and recently emancipated, was funded and organized by the American Colonization Society (ACS). The mortality rate of these settlers was the highest among settlements reported with modern recordkeeping. Of the 4,571 emigrants who arrived in Liberia between 1820 and 1843, only 1,819 survived (39.8%).