New Orleans (pictured), the first steamship on the Mississippi River, arrived at New Orleans to complete its maiden voyage.

New Orleans was the first steamboat on the western waters of the United States. Her 1811–1812 voyage from Pittsburgh, Pennsylvania, to New Orleans, Louisiana, on the Ohio and Mississippi rivers ushered in the era of commercial steamboat navigation on the western and mid-western continental rivers.

A steamship, often referred to as a steamer, is a type of steam-powered vessel, typically ocean-faring and seaworthy, that is propelled by one or more steam engines that typically move (turn) propellers or paddlewheels. The first steamships came into practical usage during the early 19th century; however, there were exceptions that came before. Steamships usually use the prefix designations of "PS" for paddle steamer or "SS" for screw steamer. As paddle steamers became less common, "SS" is incorrectly assumed by many to stand for "steamship". Ships powered by internal combustion engines use a prefix such as "MV" for motor vessel, so it is not correct to use "SS" for most modern vessels.

The Mississippi River is the primary river of the largest drainage basin in the United States. It is the second-longest river in the United States, behind only the Missouri. From its traditional source of Lake Itasca in northern Minnesota, it flows generally south for 2,340 mi (3,770 km) to the Mississippi River Delta in the Gulf of Mexico. With its many tributaries, the Mississippi's watershed drains all or parts of 32 U.S. states and two Canadian provinces between the Rocky and Appalachian mountains. The river either borders or passes through the states of Minnesota, Wisconsin, Iowa, Illinois, Missouri, Kentucky, Tennessee, Arkansas, Mississippi, and Louisiana. The main stem is entirely within the United States; the total drainage basin is 1,151,000 sq mi (2,980,000 km²), of which only about one percent is in Canada. The Mississippi ranks as the world's tenth-largest river by discharge flow, and the largest in North America.