The first steamboat on the Ohio River or the Mississippi River arrives in New Orleans, 82 days after departing from Pittsburgh.

New Orleans was the first steamboat on the western waters of the United States. Her 1811–1812 voyage from Pittsburgh, Pennsylvania, to New Orleans, Louisiana, on the Ohio and Mississippi rivers ushered in the era of commercial steamboat navigation on the western and mid-western continental rivers.

The Ohio River is a 981-mile-long (1,579 km) river in the United States. It is located at the boundary of the Midwestern and Southern United States, flowing in a southwesterly direction from Pittsburgh, Pennsylvania, to its mouth on the Mississippi River in Cairo, Illinois. It is the third largest river by discharge volume in the United States and the largest tributary by volume of the Mississippi River. It is also the sixth oldest river on the North American continent. The river flows through or along the border of six states, and its drainage basin includes parts of 14 states. Through its largest tributary, the Tennessee River, the basin includes several states of the southeastern United States. It is the source of drinking water for five million people.

The Mississippi River is the primary river of the largest drainage basin in the United States. It is the second-longest river in the United States, behind only the Missouri. From its traditional source of Lake Itasca in northern Minnesota, it flows generally south for 2,340 mi (3,770 km) to the Mississippi River Delta in the Gulf of Mexico. With its many tributaries, the Mississippi's watershed drains all or parts of 32 U.S. states and two Canadian provinces between the Rocky and Appalachian mountains. The river either borders or passes through the states of Minnesota, Wisconsin, Iowa, Illinois, Missouri, Kentucky, Tennessee, Arkansas, Mississippi, and Louisiana. The main stem is entirely within the United States; the total drainage basin is 1,151,000 sq mi (2,980,000 km²), of which only about one percent is in Canada. The Mississippi ranks as the world's tenth-largest river by discharge flow, and the largest in North America.