The Palermo rising takes place in Sicily against the Bourbon Kingdom of the Two Sicilies.

The Sicilian revolution of independence of 1848 which commenced on 12 January 1848 was the first of the numerous Revolutions of 1848 which swept across Europe. It was a popular rebellion against the rule of Ferdinand II of the House of Bourbon, King of the Two Sicilies. Three revolutions against the Bourbon ruled Kingdom of the Two Sicilies had previously occurred on the island of Sicily starting from 1800: this final one resulted in an independent state which survived for 16 months. The Sicilian Constitution of 1848 which survived the 16 months was advanced for its time in liberal democratic terms, as was the proposal of a unified Italian confederation of states. It was in effect a curtain-raiser to the end of the Bourbon kingdom of the Two Sicilies, finally completed by Giuseppe Garibaldi's Expedition of the Thousand in 1860, the Siege of Gaeta of 1860–1861 and the proclamation of the unified Kingdom of Italy.

Sicily, officially the Sicilian Region, is an island in the central Mediterranean Sea and one of the 20 regions of Italy, situated south of the Italian Peninsula in continental Europe. With 4.7 million inhabitants, including 1.2 million in and around the capital city of Palermo, it is both the largest and most populous island in the Mediterranean Sea.

The House of Bourbon is a dynasty that originated in the Kingdom of France as a branch of the Capetian dynasty, the royal House of France. Bourbon kings first ruled France and Navarre in the 16th century. A branch descended from the French Bourbons came to rule Spain in the 18th century and is the current Spanish royal family. Other branches, descended from the Spanish Bourbons, held thrones in Naples, Sicily, and Parma. Today, Spain and Luxembourg have monarchs from the House of Bourbon.

The Kingdom of the Two Sicilies was a kingdom in Southern Italy from 1816 to 1861 under the control of the House of Bourbon-Two Sicilies, a cadet branch of the Bourbons. The kingdom was the largest sovereign state by population and land area in Italy before the Italian unification, comprising Sicily and most of the area of today's Mezzogiorno and covering all of the Italian peninsula south of the Papal States.