Space Shuttle program: STS-51-L mission: Space Shuttle Challenger disintegrates after liftoff, killing all seven astronauts on board.

The Space Shuttle program was the fourth human spaceflight program carried out by the U.S. National Aeronautics and Space Administration (NASA), which accomplished routine transportation for Earth-to-orbit crew and cargo from 1981 to 2011. Its official program name was Space Transportation System (STS), taken from a 1969 plan for a system of reusable spacecraft where it was the only item funded for development, as a proposed nuclear shuttle in the plan was cancelled in 1972. It flew 135 missions and carried 355 astronauts from 16 countries, many on multiple trips.

STS-51-L was the disastrous 25th mission of NASA's Space Shuttle program and the final flight of Space Shuttle Challenger.

Space Shuttle Challenger (OV-099) was a Space Shuttle orbiter manufactured by Rockwell International and operated by NASA. Named after the commanding ship of a nineteenth-century scientific expedition that traveled the world, Challenger was the second Space Shuttle orbiter to fly into space after Columbia, and launched on its maiden flight in April 1983. It was destroyed in January 1986 soon after launch in a disaster that killed all seven crewmembers aboard.

On January 28, 1986, Space Shuttle Challenger broke apart 73 seconds into its flight, killing all seven crew members aboard. The spacecraft disintegrated 46,000 feet (14 km) above the Atlantic Ocean, off the coast of Cape Canaveral, Florida, at 16:39:13 UTC. It was the first fatal accident involving an American spacecraft while in flight.