The Vellore Mutiny is the first instance of a mutiny by Indian sepoys against the British East India Company.

The Vellore mutiny, or Vellore Revolution, occurred on 10 July 1806 and was the first instance of a large-scale and violent mutiny by Indian sepoys against the East India Company, predating the Indian Rebellion of 1857 by half a century. The revolt, which took place in the Indian city of Vellore, lasted one full day, during which mutineers seized the Vellore Fort and killed or wounded 200 British troops. The mutiny was subdued by cavalry and artillery from Arcot. Total deaths amongst the mutineers were approximately 350; with summary executions of about 100 during the suppression of the outbreak, followed by the formal court-martial of smaller numbers.

A sepoy was the designation given to an Indian infantryman armed with a musket in the armies of the the Mughal Empire and the British East India Company.

The East India Company (EIC) was an English, and later British, joint-stock company that was founded in 1600 and dissolved in 1874. It was formed to trade in the Indian Ocean region, initially with the East Indies, and later with East Asia. The company gained control of large parts of the Indian subcontinent and Hong Kong. At its peak, the company was the largest corporation in the world by various measures and had its own armed forces in the form of the company's three presidency armies, totalling about 260,000 soldiers, twice the size of the British Army at certain times.