Anglo–Spanish War: A convoy of English ships from the Levant Company manage to repel a fleet of eleven Spanish and Maltese galleys off the Mediterranean island of Pantelleria.

The Anglo-Spanish War (1585–1604) was an intermittent conflict between the Habsburg Kingdom of Spain and the Kingdom of England that was never formally declared. It began with England's military expedition in 1585 to what was then the Spanish Netherlands under the command of Robert Dudley, Earl of Leicester, in support of the Dutch rebellion against Spanish Habsburg rule.

The Levant Company was an English chartered company formed in 1592. Elizabeth I of England approved its initial charter on 11 September 1592 when the Venice Company (1583) and the Turkey Company (1581) merged, because their charters had expired, as she was eager to maintain trade and political alliances with the Ottoman Empire. Its initial charter was good for seven years and was granted to Edward Osborne, Richard Staper, Thomas Smith and William Garrard with the purpose of regulating English trade with the Ottoman Empire and the Levant. The company remained in continuous existence until being superseded in 1825. A member of the company was known as a Turkey Merchant.

The Battle of Pantelleria (1586), also known as the Fight at Pantalarea was a naval engagement during the Anglo–Spanish War off the island of Pantelleria on 13 July 1586. The encounter was between an English armed merchant fleet of five ships of the Levant Company in convoy under Edward Wilkinson and a fleet of eleven Spanish and Maltese galleys under Don Pedro de Leyva. The English managed to repel all the attacks and returned home unmolested. Although minor, the battle had significant consequences in testing English armaments used against the Spanish Armada two years later when England was under threat of invasion.

Hospitaller Malta, known in Maltese history as the Knights' Period, was a de facto state which existed between 1530 and 1798 when the Mediterranean islands of Malta and Gozo were ruled by the Order of St. John of Jerusalem. It was formally a vassal state of the Kingdom of Sicily, and it came into being when Emperor Charles V granted the islands as well as the city of Tripoli in modern Libya to the Order, following the latter's loss of Rhodes in 1522. Hospitaller Tripoli was lost to the Ottoman Empire in 1551, but an Ottoman attempt to take Malta in 1565 failed.