The Israel–Syria Mixed Armistice Commission brokers the last of four ceasefire agreements to end the 1948 Arab–Israeli War.

The Israel–Syria Mixed Armistice Commission (ISMAC) was the United Nations commission for observing the armistice between Israel and Syria after the 1948 Arab–Israeli War, as part of the Mixed Armistice Commissions (MAC). The fourth and last truce agreement, the 1949 armistice agreement, was signed between Israel and Syria on 20 July 1949 on Hill 232 near Mahanayim, ending the formal conflict in the former Mandatory Palestine. The Israeli side was represented by Lieutenant Colonel Mordechai Maklef, Yehoshua Penman and Shabtai Rosenne, while the Syrian side was represented by Colonel Fawzi Selo, Lieutenant Colonel Mohamed Nasser and Captain Afif Sizri. While the armistice agreements with Syria concluded the 1948 Arab–Israeli War, they did not mark the end of the Arab–Israeli conflict.

The 1948 Arab–Israeli War, also known as the First Arab–Israeli War, followed the civil war in Mandatory Palestine as the second and final stage of the 1948 Palestine war. The civil war became a war of separate states with the Israeli Declaration of Independence on 14 May 1948, the end of the British Mandate for Palestine at midnight, and the entry of a military coalition of Arab states into the territory of Mandatory Palestine the following morning. The war formally ended with the 1949 Armistice Agreements which established the Green Line.