The city of Guayaquil is founded by the Spanish Conquistador Francisco de Orellana and given the name Muy Noble y Muy Leal Ciudad de Santiago de Guayaquil.

Guayaquil, officially Santiago de Guayaquil, is the largest city in Ecuador and also the nation's economic capital and main port. The city is the capital of Guayas Province and the seat of Guayaquil Canton. The city is located on the west bank of the Guayas River, which flows into the Pacific Ocean at the Gulf of Guayaquil.

Conquistadors or conquistadores were Spanish and Portuguese colonizers who explored, traded with and colonized parts of the Americas, Africa, Oceania and Asia during the Age of Discovery. Sailing beyond the Iberian Peninsula, they established numerous colonies and trade routes, and brought much of the New World under the dominion of Spain and Portugal.

Francisco de Orellana was a Spanish explorer and conquistador. In one of the most improbably successful voyages in known history, Orellana managed to sail the length of the Amazon, arriving at the river's mouth on 24 August 1542. He and his party sailed along the Atlantic coast until reaching Cubagua Island, near the coast of Venezuela.