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All remaining Jews are expelled from Spain when the Alhambra Decree takes effect.

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Alhambra Decree
1492 decree expelling Jews from Spain
The Alhambra Decree was an edict issued on 31 March 1492 by the joint Catholic Monarchs of Spain, Isabella I of Castile and Ferdinand II of Aragon, ordering the expulsion of practising Jews from the Crowns of Castile and Aragon and its territories and possessions by 31 July of…Source: Wikipedia (CC BY-SA)