The Russell–Einstein Manifesto calls for a reduction of the risk of nuclear warfare.

The Russell–Einstein Manifesto was issued in London on 9 July 1955 by Bertrand Russell in the midst of the Cold War. It highlighted the dangers posed by nuclear weapons and called for world leaders to seek peaceful resolutions to international conflict. The signatories included eleven pre-eminent intellectuals and scientists, including Albert Einstein, who signed it shortly before his death on 18 April 1955. Shortly after the release, philanthropist Cyrus S. Eaton offered to sponsor a conference—called for in the manifesto—in Pugwash, Nova Scotia, Eaton's birthplace. The conference, held in July 1957, became the first of the Pugwash Conferences on Science and World Affairs.

Nuclear warfare, also known as atomic warfare, is a military conflict or prepared political strategy that deploys nuclear weaponry. Nuclear weapons are weapons of mass destruction; in contrast to conventional warfare, nuclear warfare can produce destruction in a much shorter time and can have a long-lasting radiological result. A major nuclear exchange would likely have long-term effects, primarily from the fallout released, and could also lead to secondary effects, such as "nuclear winter", nuclear famine, and societal collapse. A global thermonuclear war with Cold War-era stockpiles, or even with the current smaller stockpiles, may lead to various scenarios including human extinction.