French forces are driven out of northern Italy by Spain at the Battle of Landriano during the War of the League of Cognac.

The Kingdom of France is the historiographical name or umbrella term given to various political entities of France in the medieval and early modern period. It was one of the most powerful states in Europe from the High Middle Ages to 1848 during its dissolution. It was also an early colonial power, with colonies in Asia and Africa, and the largest being New France in North America geographically centred on the Great Lakes.

Habsburg Spain refers to Spain and the Hispanic Monarchy, also known as the Catholic Monarchy, in the period from 1516 to 1700 when it was ruled by kings from the House of Habsburg. In this period the Spanish Empire was at the zenith of its influence and power. During this period, Spain held many territories, including American continental holdings and the West Indies; European territories like the Low Countries, Italian territories, Portugal and parts of France; and the Philippines and other possessions in Southeast Asia. The period of Spanish history has also been referred to as the "Age of Expansion".

The Battle of Landriano took place on 21 June 1529, between the French army under Comte de Saint-Pol and the Imperial–Spanish army commanded by Don Antonio de Leyva, Duke of Terranova in the context of the War of the League of Cognac. The French army was destroyed and the battle's strategic result was that the struggle between Francis I of France and Charles V, Holy Roman Emperor for control of northern Italy was temporarily at an end.

The War of the League of Cognac (1526–1530) was fought between the Habsburg dominions of Charles V—primarily the Holy Roman Empire and Spain—and the League of Cognac, an alliance including the Kingdom of France, Pope Clement VII, the Republic of Venice, the Kingdom of England, the Duchy of Milan, and the Republic of Florence.