Battle of Raphia: Ptolemy IV Philopator of Egypt defeats Antiochus III the Great of the Seleucid kingdom.

The Battle of Raphia was fought on 22 June 217 BC near modern Rafah between the forces of Ptolemy IV Philopator, king and pharaoh of Ptolemaic Egypt and Antiochus III the Great of the Seleucid Empire during the Syrian Wars. It was one of the largest battles of the Hellenistic kingdoms and of the ancient world, and determined the sovereignty of Coele-Syria.

Ptolemy IV Philopator was the fourth pharaoh of Ptolemaic Egypt from 221 to 204 BC.

Antiochus III the Great was the sixth ruler of the Seleucid Empire, reigning from 223 to 187 BC. He ruled over the region of Syria and large parts of the rest of West Asia towards the end of the 3rd century BC. Rising to the throne at the age of eighteen in April/June 223 BC, his early campaigns against the Ptolemaic Kingdom were unsuccessful, but in the following years Antiochus gained several military victories and substantially expanded the empire's territory. His traditional designation, the Great, reflects an epithet he assumed. He also assumed the title Basileus Megas, the traditional title of the Persian kings. A militarily active ruler, Antiochus restored much of the territory of the Seleucid Empire, before suffering a serious setback, towards the end of his reign, in his war against the Roman Republic. Declaring himself the "champion of Greek freedom against Roman domination", he waged a four-year war against Rome beginning in mainland Greece in the autumn of 192 BC before being decisively defeated at the Battle of Magnesia. He died three years later on campaign in the east.

The Seleucid Empire was a Greek state in West Asia during the Hellenistic period. It was founded in 312 BC by the Macedonian general Seleucus I Nicator, following the division of the Macedonian Empire founded by Alexander the Great, and ruled by the Seleucid dynasty until its annexation by the Roman Republic under Pompey in 63 BC.