A blowout at the Ixtoc I oil well in the southern Gulf of Mexico causes at least 3,000,000 barrels (480,000 m3) of oil to be spilled into the waters, the second-worst accidental oil spill ever recorded.

Ixtoc 1 was an exploratory oil well being drilled by the semi-submersible drilling rig Sedco 135 in the Bay of Campeche of the Gulf of Mexico, about 100 km (62 mi) northwest of Ciudad del Carmen, Campeche in waters 50 m (164 ft) deep. On 3 June 1979, the well suffered a blowout resulting in the largest oil spill in history at its time. To-date, it remains the second largest marine oil spill in history after the Deepwater Horizon oil spill.

The Gulf of Mexico is an oceanic basin and a marginal sea of the Atlantic Ocean, mostly surrounded by the North American continent. It is bounded on the northeast, north, and northwest by the Gulf Coast of the United States; on the southwest and south by the Mexican states of Tamaulipas, Veracruz, Tabasco, Campeche, Yucatán, and Quintana Roo; and on the southeast by Cuba. The coastal areas along the Southern U.S. states of Texas, Louisiana, Mississippi, Alabama, and Florida, which border the Gulf on the north, are occasionally referred to as the "Third Coast" of the United States, but more often as "the Gulf Coast".

An oil spill is the release of a liquid petroleum hydrocarbon into the environment, especially the marine ecosystem, due to human activity, and is a form of pollution. The term is usually given to marine oil spills, where oil is released into the ocean or coastal waters, but spills may also occur on land. Oil spills can result from the release of crude oil from tankers, offshore platforms, drilling rigs, and wells. They may also involve spills of refined petroleum products, such as gasoline and diesel fuel, as well as their by-products. Additionally, heavier fuels used by large ships, such as bunker fuel, or spills of any oily refuse or waste oil, contribute to such incidents. These spills can have severe environmental and economic consequences.