The launch of Gemini 4, the first multi-day space mission by a NASA crew. Ed White, a crew member, performs the first American spacewalk.

Gemini 4 was the second crewed spaceflight in NASA's Project Gemini, occurring in June 1965. It was the tenth crewed American spaceflight. Astronauts James McDivitt and Ed White orbited the Earth 66 times in four days, making it the first US flight to approach the five-day flight of the Soviet Vostok 5. The highlight of the mission was the first space walk by an American, during which White floated free outside the spacecraft, tethered to it, for approximately 23 minutes.

The National Aeronautics and Space Administration is an independent agency of the US federal government responsible for the United States's civil space program, aeronautics research and space research. Established in 1958, it succeeded the National Advisory Committee for Aeronautics (NACA) to give the American space development effort a distinct civilian orientation, emphasizing peaceful applications in space science. It has since led most of America's space exploration programs, including Project Mercury, Project Gemini, the 1968–1972 Apollo program missions, the Skylab space station, and the Space Shuttle. Currently, NASA supports the International Space Station (ISS) along with the Commercial Crew Program and oversees the development of the Orion spacecraft and the Space Launch System for the lunar Artemis program.

Edward Higgins White II was an American aeronautical engineer, United States Air Force officer, test pilot, and NASA astronaut. He was a member of the crews of Gemini 4 and Apollo 1.

Extravehicular activity (EVA) is any activity done by an astronaut in outer space outside a spacecraft. In the absence of a breathable Earthlike atmosphere, the astronaut is completely reliant on a space suit for environmental support. EVA includes spacewalks and lunar or planetary surface exploration. In a stand-up EVA (SEVA), an astronaut stands through an open hatch but does not fully leave the spacecraft. EVAs have been conducted by the Soviet Union/Russia, the United States, and China; astronauts from Canada, Japan, Brazil, the United Arab Emirates, and the European Space Agency have also participated in EVAs conducted by those nations.