A fire at a day-care center kills 49 people in Hermosillo, Mexico.

The ABC Day Care Center Fire in Hermosillo, Sonora, Mexico, took place on Friday, June 5, 2009. Forty-nine children died that day and the death toll subsequently rose as additional children succumbed to their injuries. By June 7th, 44 toddlers and infants were reported killed as a result of the blaze. Five additional children died in the coming weeks, raising the final death toll to 49. Over 40 infants and toddlers and six adults were hospitalized with burns.

Hermosillo, formerly called Pitic, is a city in the center of the northwestern Mexican state of Sonora. It is the municipal seat of the Hermosillo municipality, the state's capital and largest city, as well as the primary economic center for the state and the region. As of 2020, the city has a population of 936,263, making it the 18th largest city in Mexico. The recent increase in the city's population is due to expanded industrialization, especially within the automotive industry.

June 5 is the 156th day of the year in the Gregorian calendar; 209 days remain until the end of the year.